Chronic granulomatous disease (CGD): an immunodeficiency diagnosed in pediatric ICU

Background This paper aims at showing a severe case of a patient with Chronic Granulomatous Disease (CGD), an immunodeficiency which is not so uncommon, affecting 1/ 250000 born alive, and which is due to phagocytic dysfunction. It is characterized by inability of phagocytic cells to produce hydrogen peroxide and other oxidants needed to eliminate microorganisms, in addition there is excessive accumulation of immune cells into aggregates, known as granulomas, at sites of infection or inflammation. The patient may experience fungal or bacterial infections affecting the skin, lungs (Aspergillus pneumonias), lymph nodes, liver (liver abscesses 90% caused by Staphylococcus), bones (osteomyelitis), and granulomas which may lead to obstruction of gastrointestinal and urinary tracts.